tr A2BDH2 A2BDH2_PONAB Major prion protein OS=Pongo

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However, the biological mechanisms of AGAP2-AS1 in GBM progression are still unclear. Herein, we found that AGAP2-AS1 expression was up-regulated in GBM tissues and cells. High AGAP2-AS1 expression may predict a poor prognosis in GBM patients. RT-qPCR was performed to detect the differential expression of AGAP2-AS1 in tumor tissues and adjacent normal tissues. To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells.

Agap2-as1

To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells. CCK-8 assay was used to detect cell proliferation. AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test.

Mechanistically, AGAP2-AS1 can repress LATS2 and KLF2 transcription via binding with EZH2 and LSD1 .

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13 … 2021-01-01 AGAP2-AS1 upregulates the MMP2 expression, we first analyzed the cellular localization of AGAP2-AS1 using immunofluorescence. As shown in Figure 3A, AGAP2-AS1 was localized mainly in the cytoplasm in TPC1 and K1 cells. To investigate whether AGAP2-AS1 may SP1 induced AGAP2-AS1 plays an important role in tumorigenesis.

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AGAP2-AS1 enhanced the chemoresistance of CRC cells to 27 Jul 2019 Silencing Long Non-Coding RNA AGAP2-AS1 Upregulates microRNA-195-5p to Repress Migration and Invasion of Esophageal Cancer Cells 22 Nov 2016 The expression of four lncRNAs in different grades showed that AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". Journal of Cell Science. 118 (Pt 15): &n AGAP2-AS1 Silencing Inhibits Proliferation, Migration, and Invasion but Promotes Apoptosis of EC Cells by Decreasing FOSL1 Expression via. Upregulation of 12, ENSG00000229950, TFAP2A-AS1, 1.70E-15, 8.59E-13, 1.89.

18 Feb 2021 However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma ( PTC) remain unclear. Thus, in this study, we aimed to explore Moreover, lncRNA AGAP2-AS1 promotes cell proliferation and invasion in gastric cancer [13].
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Click the + buttons to view associations for AGAP2-AS1 from the datasets below.

The current study aimed to elucidate the role of lncRNA AGAP2-AS1/miR-195-5p/PDZ and LIM domain 5 (PDLIM5) in prostate cancer 2018-08-29 · AGAP2-AS1 was upregulated and transcriptionally induced by SP1 in breast cancer.
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Additionally, we investigated the functional impact of AGAP2-AS1 on tumor migration, invasion and proliferation during EOC progression through a series of in vitro and in vivo assays. Moreover, we also explored the molecular events that occurred AGAP2-AS1 was up-regulated and associated with poor prognosis in GBM. Knockdown of AGAP2 -AS1 suppressed proliferation and invasion, and facilitated apoptosis in GBM cells . To explore the functional relevance of AGAP2AS1 in - GBM cells, we interfered endogenous AGAP2-AS1 expression in U87/MG and U251/MG cells by AGAP2-AS1 was demonstrated as an oncogene in several cancers, including glioblastoma (GBM). However, the biological mechanisms of AGAP2-AS1 in GBM progression are still unclear.

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Gene ID Unique ID sequence Library number Human

Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test. Title: AGAP2-AS1 regulates AGAP2 mRNA levels Abstract: AGAP2-AS1 is an antisense lncRNA situated in the 3’ end of AGAP2. It is becoming now more widely accepted that 3’ antisense lncRNAs can modify the expression of their gene counterparts and we demonstrate here that this is the case as well for the tandem AGAP2 – AGAP2-AS1.